06 · Reports, trials and sign-off
A Twin capability
Relevant clinical-trial opportunities, for review.
From match to enrolment
A potential match is the first of five steps
- 01
Potential match
The case's diagnosis, biomarkers, prior treatment and location appear compatible with some published criteria.
TrialGraph · for review
- 02
Clinician review
The treating oncologist considers whether the trial is appropriate to discuss with the patient.
Treating oncologist
- 03
Screening
The trial team assesses full eligibility criteria, which often go beyond what is in registries.
Trial team
- 04
Confirmed eligibility
Only the trial team can confirm that a patient meets the criteria.
Trial team
- 05
Enrolment
Depends on consent, slot availability and sponsor acceptance.
Patient · trial team · sponsor
How matching works
Comparing the case with published criteria
Trial matching compares structured features of the case — disease, biomarkers, prior treatment and location — with eligibility criteria published in trial registries. Each potential match comes with the rationale: which criteria appear to be met, which are unknown, and which need checking.
Registry information can be incomplete or out of date, and recruitment status changes. Potential matches appear in the fourth component of the Twin report, alongside treatment options to evaluate.
Boundaries
The treating oncologist owns every decision. Every Twin report is reviewed and signed by the treating oncologist, then taken to KPCIRC's Molecular Tumour Board.
KPCIRC sign-off process