04 · 21 proprietary layers
Layer 9 of 21 · Tumour behaviour
Tumour Microenvironment Stromal, immune and microenvironmental context.
Why it's needed
What tumour microenvironment features are represented in the available data?
What it draws on
3 of 8 evidence domains.
What it produces
Microenvironment-related observations or interpreted context.
Why it's essential
Layer 9 of 21.
1 · What it does
What Tumour Microenvironment does
Tumours grow among blood vessels, connective tissue (stroma) and immune cells, and that surrounding context affects how they behave. This layer is intended to describe what the available data can say about the microenvironment, and how confidently.
2 · Scientific question
The question it addresses
What tumour microenvironment features are represented in the available data?
Intended function
Explain the intended integration of stromal, immune and other microenvironmental context.
3 · Data inputs and required context
What it draws on
- 05 Immune landscape
- 02 Tumour biology
- 03 Clinical context
Immune biomarkers, any RNA-derived signatures and relevant pathology information.
4 · Scientific basis
The science behind it
Scientific basis
Microenvironment features can be measured directly, for example by pathology, immunohistochemistry or spatial methods, or inferred computationally, for example from bulk RNA expression. DNA-only data provide limited direct information about the microenvironment.
5 · Output and evidence sources
What it produces
Main output
Microenvironment-related observations or interpreted context.
Output type
- Computational inference. Estimated by analysis of available data rather than measured directly.
- Clinical-context integration. Depends on clinical information supplied by the treating team.
6 · Why it\u2019s essential
How it powers the Twin
Adds context to ImmuneLens and PhenoMap findings in the molecular-findings section.
Report section
7 · Why it\u2019s needed
What it changes — for doctors, patients and researchers
Clinicians
Microenvironment context with its source (measured, assay-derived or inferred) stated.
Doctor & Clinical Team8 · Dependencies and limitations
Limitations
- Each item must state whether it was directly measured, derived from a tested assay or computationally inferred.
- Without RNA or pathology inputs, little can be said about the microenvironment.
9 · Review and uncertainty
How the output is handled
Output status
An AI-assisted analytical output presented as structured findings for clinician review. It becomes part of a report only after the treating oncologist has reviewed and signed it.
How uncertainty is communicated
Observations are tagged by evidence source, and absent inputs are reported as absent rather than inferred.
10 · Claim boundary
What this layer does not establish
It does not provide a measured map of the tumour microenvironment unless such measurements were supplied.
The treating oncologist owns every decision. Every Twin report is reviewed and signed by the treating oncologist, then taken to KPCIRC's Molecular Tumour Board.
KPCIRC sign-off process