Stages 03–04 · Screen & observe

Candidate-drug screening.

Candidate drugs and combinations are tested in the engineered model for measurable outcomes. Responses are recorded with their limits kept for review.

How screening is structured

Candidates, controls and replicates

Screening compares how the engineered model responds to candidate drugs or combinations against appropriate controls, measuring pre-defined outcomes. The candidates in scope, the measured endpoints and the experimental methods are defined for each study.

AVATAR does not imply universal drug screening: only the candidates in scope are tested.

Screening layout

Each row is a candidate condition, screened in replicate wells against the engineered model. The candidates in scope are defined for each study.

Reading a screening result

Four things a screening result is not

Not a prescription
A candidate in an output is not a treatment recommendation.
Not an approval
It says nothing about regulatory approval for the patient's indication.
Not safety evidence
Tolerability in a fly is not evidence of safety in a person.
Not proof of efficacy
A response in flies is not proof of efficacy in a patient.

Stage summaries

Screening and observation

Screen · AVATAR Discovery Process

Candidate-drug screening

Experimental model observation

What happens: Candidate drugs and combinations are tested in the engineered model for measurable outcomes.
Inputs: The engineered model and the candidate drugs or combinations defined for the study.
Intended output: Measured responses in the model.
What it establishes: How the model responded to the candidates under the conditions tested.
Why it matters: Experimental evidence on candidates, gathered before any decision is made for the patient.

Observe · AVATAR Discovery Process

Experimental observations

Experimental model observationFor oncologist assessment

What happens: Responses are recorded and quantified for review.
Inputs: Screening results.
Intended output: An observation summary for each candidate and combination.
What it establishes: Experimental evidence that adds to computational prediction.
Why it matters: It adds measured biology to the molecular prediction.

See what AVATAR delivers.

Research outputs Evidence