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OnKommon
OnKommon Twin

Scientific framework

Explore the 21 analytical layers.

One continuous loop: the patient above, the living model below. Each layer addresses a defined scientific question, produces a specific kind of output, and has stated limits on what it can establish.
Search the directoryUnderstand variant evidence
The 21 OnKommon Twin analytical layersA ring of 21 segments, numbered 1 to 21 and coloured by the five layer groups: six shared core layers (1–6), tumour behaviour (7–10), clinical integration (11–14), action and continuity (15–18) and longitudinal intelligence (19–21).1. CloneTrace — Clonality and tumour evolution12. SourceGuard — Somatic and germline interpretation23. SigPrint — Mutational signatures and aetiology34. PhenoMap — Molecular and cellular phenotype45. ImmuneLens — Immune landscape and biomarkers56. AccessMatch — Actionable alterations and targetability67. Kinetix — Growth dynamics and evolutionary trajectory78. ResistMap — Resistance mechanisms and bypass routes89. Tumour Microenvironment — Stromal, immune and microenvironmental context910. RNA Expression & Signatures — Expression patterns and signatures1011. Clinical Correlation — Clinical-context integration1112. Imaging Integration — Radiology and imaging biomarkers1213. Staging & Prognostic Models — Stage, risk models and outcome estimates1314. Treatment Response Prediction — Likelihood of response and resistance1415. TwinBirth — Creation of the patient's digital twin1516. TrialGraph — Clinical trial matching and prioritisation1617. ToxCast — Therapy toxicity risk and tolerability1718. CostPath — Treatment pathways and cost considerations1819. EvidencePulse — Continuous evidence monitoring1920. DecisionLedger — Tracking decisions, rationale and outcomes2021. Dynamic Twin Updates — Periodic model updates over time2121ANALYTICALLAYERS

Try it · Ask the layers

Ask the layers a question.

Each layer exists to answer a specific question — and each states what it cannot establish.

Answered by layer 2

SourceGuard

Somatic and germline interpretation

Classification or context of findings, and items that may need confirmation or clinical genetics review.

What it does not establish

A 'possibly germline' flag is not a hereditary diagnosis. Confirmatory germline testing with appropriate consent and counselling is required.

Explore SourceGuard

How to read this directory

Names are official. Explanations are layered.

Each layer page then explains the question it addresses, its intended output, what it draws on and — just as important — what it does not establish.

Not every layer runs for every case. Which layers contribute depends on the testing pathway and the information available. Every layer output is presented for the treating oncologist's review; none is a decision.

Output types used on every layer

  • Assay-derived finding. Reported from laboratory sequencing data, subject to assay scope and quality.
  • Computational inference. Estimated by analysis of available data rather than measured directly.
  • Evidence-linked interpretation. Connects a finding to published or curated evidence, which has a source and a date.
  • Clinical-context integration. Depends on clinical information supplied by the treating team.
  • Twin workflow function. Part of how the Twin is created, reviewed or updated, rather than an analytical result.
  • Structured record. A governed record of what was reviewed or decided.

Directory

Search and filter all 21 layers

Showing 21 of 21 layers

Five groups

How the layers fit together

The layers into five groups that move from what the tumour contains, to how it behaves, to the clinical picture, to action and continuity, to keeping the picture current.

01 · Layers 1–6

Six shared core layers

What the tumour's molecular profile contains: clonal structure, origin of variants, mutational patterns, phenotype, immune biomarkers and targetability.

02 · Layers 7–10

Tumour behaviour

How the tumour may behave: growth dynamics, resistance routes, the surrounding microenvironment and expressed genes.

03 · Layers 11–14

Clinical integration

Placing molecular findings in the clinical picture: case context, imaging, staging and response-related evidence.

04 · Layers 15–18

Action and continuity

From analysis to options for review: creating the baseline Twin, trial matching, tolerability and cost considerations.

05 · Layers 19–21

Longitudinal intelligence

Keeping the picture current: evidence monitoring, a record of decisions, and periodic updates to the Twin.

Accessible list

All 21 layers at a glance

A plain list alternative to the interactive ring and directory.
  1. 1CloneTraceClonality and tumour evolution
  2. 2SourceGuardSomatic and germline interpretation
  3. 3SigPrintMutational signatures and aetiology
  4. 4PhenoMapMolecular and cellular phenotype
  5. 5ImmuneLensImmune landscape and biomarkers
  6. 6AccessMatchActionable alterations and targetability
  7. 7KinetixGrowth dynamics and evolutionary trajectory
  8. 8ResistMapResistance mechanisms and bypass routes
  9. 9Tumour MicroenvironmentStromal, immune and microenvironmental context
  10. 10RNA Expression & SignaturesExpression patterns and signatures
  11. 11Clinical CorrelationClinical-context integration
  12. 12Imaging IntegrationRadiology and imaging biomarkers
  13. 13Staging & Prognostic ModelsStage, risk models and outcome estimates
  14. 14Treatment Response PredictionLikelihood of response and resistance
  15. 15TwinBirthCreation of the patient's digital twin
  16. 16TrialGraphClinical trial matching and prioritisation
  17. 17ToxCastTherapy toxicity risk and tolerability
  18. 18CostPathTreatment pathways and cost considerations
  19. 19EvidencePulseContinuous evidence monitoring
  20. 20DecisionLedgerTracking decisions, rationale and outcomes
  21. 21Dynamic Twin UpdatesPeriodic model updates over time
  • 01 Six shared core layers · Layers 1–6
  • 02 Tumour behaviour · Layers 7–10
  • 03 Clinical integration · Layers 11–14
  • 04 Action and continuity · Layers 15–18
  • 05 Longitudinal intelligence · Layers 19–21

See how the layers come together in a report.

Reports & outputsRequest a demonstration

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Longitudinal monitoring

Every change goes in.

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