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Sentinel Blood – Monitoring for Blood-Based Contexts · OnKommon
Sentinel · Blood

Sentinel Blood — Monitoring for blood-based contexts.

SENTINEL · MONITORING FOR BLOOD-BASED CONTEXTS

Sentinel Blood is continuous monitoring for blood-based and haematological cancers on active treatment. It follows disease-specific molecular markers over time, so your team can see whether treatment is working and respond early if the picture changes.

Learn How It Works Serial Monitoring
What It Monitors

2 · What it monitors

Condition-appropriate molecular markers — for example markers such as NPM1 or BCR-ABL1, or B-cell clonality signals, where relevant — tracked over time from a blood draw, each result read against your baseline.

How It Works

3 · How it works

Baseline → Scheduled draws → Trend interpretation → Clinician review

1

Baseline

Establish your molecular starting point.

2

Scheduled draws

Monitoring on your chosen Track (2 / 4 / 6 per year).

3

Trend interpretation

The engine reads the direction of travel, not just one value.

4

Clinician review

A meaningful change triggers KPCIRC review and a plan.

Honest Limits

4 · Honest limits

We believe in transparency about what a test can and cannot do.

Monitoring shows trends and can flag change early, but it does not replace your haematologist's assessment or scheduled testing, and no single result should be read in isolation. Decisions are made by your clinical team.

Terminology

TERMINOLOGY ON THIS PAGE

The words you will see, in plain language

Term / What it means
ctDNACirculating tumour DNA — tumour DNA fragments a blood test can read over time.
Resistance mutationA new change that lets a cancer escape a treatment that was working.
Molecular progressionA rise in ctDNA signalling the cancer is advancing — often before a scan shows it.
VAFVariant allele frequency — how much of a mutation is present; tracked up or down over time.
Serial monitoringRepeat testing at intervals to watch trend, not just a single snapshot.
Important information about this test

Sentinel Blood is a genomic (DNA-based) test offered for use by qualified healthcare professionals. It is intended to support — not replace — clinical judgement, and must be interpreted alongside your full clinical history, other investigations, and applicable guidelines.

  • • A result is not a diagnosis and does not by itself decide treatment.
  • • A "not detected" or normal result does not rule out cancer or a genetic change.
  • • Not all cancers release enough DNA into blood to be detected.
  • • The test does not guarantee access to any medicine, its regulatory approval, insurance cover, or that a therapy will work.
  • • Sample-collection kits are for use by qualified phlebotomists only — not for self-testing or self-sampling.
  • • Confirmatory testing may be required.

Regulatory status (India). OnKommon's registration of its genomic tests as in-vitro diagnostic (IVD) medical devices with the Central Drugs Standard Control Organisation (CDSCO) is in progress (IVD class pending). Sequencing and variant calling are performed by an accredited laboratory partner (College of American Pathologists — CAP-accredited; ISO 15189) following international guidelines (ACMG/AMP/ASCO/CAP) using a CE-IVD certified variant database. The OnKommon interpretation engine is provided for research and decision-support use. Marketing follows the Drugs and Magic Remedies (Objectionable Advertisements) Act, 1954 and applicable Indian advertising standards.

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